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Gris PegŪ
Griseofulvin 330
Ultramicrosize Tablets, USP
Also see:
Griseofulvin
Fulvicin
Drug Uses
Gris-PEG is prescribed for the treatment
of the following ringworm infections: Athlete's foot, Barber's itch
(inflammation of the facial hair follicles), Ringworm of the body, Ringworm of
the groin and thigh, Ringworm of the nails, Ringworm of the scalp. Because
Gris-PEG is effective only for certain types of fungal infections, before
treatment your doctor may perform tests to identify the source of infection.
How Taken
Accurate diagnosis of the infecting
organism is essential. Adults: Daily administration of 330 mg (as a single dose
or in divided amounts) will give a satisfactory response. Children:
Approximately 3.3 mg per pound of body weight per day is an effective dose for
most children.
Warnings/Precautions
Because Gris-PEG can make you sensitive to
light, avoid exposure to intense natural or artificial sunlight. Notify your
doctor if you develop lupus erythematosus (a form of rheumatism) or a lupus-like
condition. Signs and symptoms of lupus include arthritis, red butterfly rash
over the nose and cheeks, tiredness, weakness, sensitivity to sunlight, and skin
eruptions. If you are being treated with Gris-PEG for an extended period of
time, your doctor should perform regular tests, including periodic monitoring of
kidney function, liver function, and blood cell production. Gris-PEG has not
been proved safe and effective for the prevention of fungal infections. Gris-PEG
may decrease the effectiveness of birth-control pills. Use additional protection
while you are taking Gris-PEG. Men should wait at least 6 months after finishing
therapy with Gris-PEG before they father a child. Women should avoid becoming
pregnant while they are taking the drug.
Missed Dose
Take the missed dose as soon as you
remember. If it is almost time for your next dose, skip the one you missed and
go back to your regular schedule. Do not take 2 doses at once.
Possible Side Effects
When adverse reactions occur, they are
most commonly of the hypersensitivity type such as skin rashes, urticaria,
erythema multiform-like drug reactions, and rarely, angioneurotic edema, and may
necessitate withdrawal of therapy and appropriate countermeasures. Paresthesias
of the hands and feet have been reported rarely after extended therapy. Other
side effects reported occasionally are oral thrush, nausea, vomiting, epigastria
distress, diarrhea, headache, fatigue, dizziness, insomnia, mental confusion,
and impairment of performance of routine activities. Administration of the drug
should be discontinued if granulocytopenia occur. When rare, serious reactions
occur with Gris-PEG, they are usually associated with high dosages, long periods
of therapy, or both.
Storage
Store Gris-PEG tablets at controlled room
temperature 15°-30°C (59°-86°F) in tight, light-resistant containers.
Overdose
Any medication taken in excess can have
dangerous consequences. If you suspect an overdose of Gris-PEG, seek emergency
medical treatment immediately.
More Information
Gris-PEG may intensify the effects of
alcohol. If you drink alcohol while taking this medication, your heart may start
beating faster and your skin may be flushed. If Gris-PEG is taken with certain
other drugs, the effects could be increased, decreased, or altered. It is
especially important to check with your doctor before combining Gris-PEG with
the following: Blood-thinning drugs such as Coumadin, Barbiturates such as
Phenobarbital, Oral Contraceptives.
Griseofulvin Tablets contain ultramicrosize crystals of griseofulvin, an
antibiotic derived from a species of Penicillium. Griseofulvin crystals are
partly dissolved in polyethylene glycol 8000 and partly dispersed throughout the
tablet matrix.
Each Griseofulvin Tablet contains 330 mg ultramicrosize griseofulvin, USP.
The inactive ingredients for Griseofulvin 330 Tablets include: corn starch,
lactose monohydrate, magnesium stearate, PEG, and sodium lauryl sulfate.
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