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Detrol® LA
tolterodine tartrate
extended release capsules
Also see:
Detrol
Drug Uses
Detrol LA capsules are once daily extended
release capsules indicated for the treatment of overactive bladder with symptoms
of urge urinary incontinence, urgency, and frequency.
How Taken
Detrol LA comes as a tablet and an
extended-release (long-acting) capsule to take by mouth. The tablet is usually
taken twice a day. The extended-release capsule is usually taken once a day with
liquids. Follow the directions on your prescription label carefully, and ask
your doctor or pharmacist to explain any part you do not understand. Take Detrol
LA exactly as directed. Do not take more or less of it or take it more often
than prescribed by your doctor. Swallow the extended-release capsules whole; do
not split, chew, or crush them.
Warnings/Precautions
Do not take Detrol LA if you have a
blockage of the urinary tract (difficulty urinating); or a blockage in the
intestines. Before taking Detrol LA, tell your doctor if you have liver disease;
kidney disease; or glaucoma. You may not be able to take Detrol LA, or you may
require a dosage adjustment or special monitoring if you have any of the
conditions listed above. Detrol LA is in the FDA pregnancy category C. This
means that it is not known whether Detrol LA will be harmful to an unborn baby.
Do not take Detrol LA without first talking to your doctor if you are pregnant
or could become pregnant during treatment. It is not known whether Detrol LA
will harm a nursing infant. Do not take Detrol LA without first talking to your
doctor if you are breast-feeding a baby.
Missed Dose
If you miss a dose of this medicine, take
it as soon as possible. If it is almost time for your next dose, skip the missed
dose and go back to your regular dosing schedule. Do NOT take 2 doses at once.
Possible Side Effects
If you experience an allergic reaction
(difficulty breathing; closing of your throat; swelling of your lips, tongue, or
face; or hives), stop taking Detrol LA and seek emergency medical attention.
Other, less serious side effects may be more likely to occur. Continue to take
Detrol LA and talk to your doctor if you experience dry mouth, dryness of the
eyes, blurred vision or large pupils, upset stomach, headache, constipation,
difficulty urinating, drowsiness, or dizziness. Side effects other than those
listed here may also occur. Talk to your doctor about any side effect that seems
unusual or that is especially bothersome.
Storage
Store at controlled room temperature 20°
to 25° C (68° to 77° F).
Overdose
Seek emergency medical attention. Symptoms
of Detrol LA overdose are not known but might include restlessness, tremor,
irritability, seizures, delirium, hallucinations, flushing, fever, nausea,
vomiting, a fast heartbeat and possibly coma.
More Information
Use caution when driving, operating
machinery, or performing other hazardous activities. Detrol LA may cause
dizziness, drowsiness, or blurred vision. If you experience dizziness,
drowsiness, or blurred vision, avoid these activities. Use alcohol cautiously.
Alcohol may increase drowsiness and dizziness while taking Detrol LA. Avoid
becoming overheated in hot weather. Detrol LA may increase the risk of heat
stroke because it may decrease sweating. Drink plenty of fluid to maintain
adequate hydration.
Detrol LA Capsules contain tolterodine tartrate.
The active moiety, tolterodine, is a muscarinic receptor antagonist. The
chemical name of tolterodine tartrate is
(R)-N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine L-hydrogen tartrate.
The empirical formula of tolterodine tartrate is C26H37NO7,
and its
molecular weight is 475.6. The structural formula of tolterodine tartrate is
represented below.
Tolterodine tartrate is a white, crystalline powder. The pKa value is 9.87 and
the solubility in water is 12 mg/mL. It is soluble in methanol, slightly soluble
in ethanol, and practically insoluble in toluene. The partition coefficient (Log
D) between n-octanol and water is 1.83 at pH 7.3.
Detrol LA for oral administration contains 2 mg or 4 mg of tolterodine tartrate.
Inactive ingredients are sucrose, starch, hypromellose, ethylcellulose, medium
chain triglycerides, oleic acid, gelatin, and FD&C Blue #2. The 2-mg capsules
also contain yellow iron oxide. Both capsule strengths are imprinted with a
pharmaceutical grade printing ink that contains shellac glaze, titanium dioxide,
propylene glycol, and simethicone.
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