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DenavirŪ
See
also:
Famvir Valtrex
Drug Uses
Denavir is a topical antiviral medication
used for recurrent cold sores (herpes labialis) on the lips and face in
otherwise healthy adult patients. Denavir topical may also be used for purposes
other than those listed in this medication guide.
How Taken
Apply Denavir every two hours during
waking hours for four days to your cold sore with your finger or a cotton swab.
Wash hands with soap and water to prevent it from coming into contact with your
eyes or other areas; to prevent irritation and to prevent spread of the herpes
virus.
Warnings/Precautions
Denavir is a topical cream that is applied
externally on the lips and face. Do not apply Denavir on mucous membranes inside
the mouth, nose, genital or rectal areas. Denavir topical is in the FDA
pregnancy category B. This means that it is unlikely to harm an unborn baby. Do
not use Denavir topical during pregnancy without first talking to your doctor.
It is not known whether Denavir topical passes into breast milk. Do not use
Denavir topical if you are breast-feeding a baby without first talking to your
doctor.
Missed Dose
Use the missed dose as soon as you
remember. However, if it is almost time for your next dose, skip the dose you
missed and use only your next regularly scheduled dose.
Possible Side Effects
Serious side effects have not been
reported with the use of Denavir topical. Other less serious side effects may be
more likely to occur. Continue to use Denavir topical and talk to your doctor if
you experience: headache; local numbness or tingling where the cream is applied;
changes in taste; rash; irritation at the application site. Side effects other
than those listed here may also occur. Talk to your doctor about any side effect
that seems unusual or that is especially bothersome.
Storage
Store at controlled room temperature,
20°-25°C (68°-77°) away from moisture and heat.
Overdose
An overdose of Denavir topical is unlikely
to threaten life. If an excessive amount of the cream has been used, or if the
cream has been ingested, contact a poison control left or an emergency room for
advice.
More Information
Do not use other topical medications to
treat the same area at them same time as Denavir topical, unless otherwise
directed by your doctor. No other medicines have been reported to interact with
Denavir topical. Talk to your doctor or pharmacist before taking other
prescription or over-the-counter medications during treatment with Denavir
topical.
Denavir contains penciclovir, an antiviral agent
active against herpes viruses. Denavir is available for topical administration
as a 1% white cream. Each gram of Denavir contains 10 mg of penciclovir and the
following inactive ingredients: cetomacrogol 1000 BP, cetostearyl alcohol,
mineral oil, propylene glycol, purified water and white petrolatum.
Chemically penciclovir is known as
9-[4-hydroxy-3-(hydroxymethyl)butyl] guanine.
Its molecular formula is C10H15N5O3
its molecular weight is 253. 26. It is a
synthetic acyclic guanine derivative.
Penciclovir is a white to pale yellow solid. At 20° C it has a solubility of 0.2
mg/mL in methanol, 1.3 mg/mL in propylene glycol, and 1.7 mg/mL in water. In
aqueous buffer (pH 2) the solubility is 100 mg/mL. Penciclovir is not
hygroscopic. Its partition coefficient in n-octanol/water at pH 7. 5 is 0.024 (logP=-1.62).
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