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Cleocin T Gel®
Drug Uses
Cleocin T is used to treat acne vulgaris.
How Taken
Apply a thin film of Cleocin T Topical
Solution or use a Cleocin T Topical Solution pledget for the application of
Cleocin T twice daily to affected area. You may use more than one pledget. Use
each pledget only once and then discard it.
Warnings/Precautions
It is not known whether clindamycin is
excreted in human milk following use of Cleocin T. However, orally and
parenterally administered clindamycin has been reported to appear in breast
milk.
Missed Dose
If you miss a dose, use it as soon as you
remember. If it is near the time of the next dose, skip the missed dose and
resume your usual dosing schedule. Do not double the dose to catch up.
Possible Side Effects
Orally and parenterally administered
Cleocin T has been associated with severe colitis which may end fatally.
Abdominal pain and gastrointestinal disturbances as well as gram-negative
folliculitis have also been reported in association with the use of topical
formulations of clindamycin.
Storage
Do not use pledget if the seal is broken.
Discard after single use. Keep all liquid dosage forms in containers tightly
closed out of the reach of children.
Overdose
Topically applied Cleocin T can be
absorbed in sufficient amounts to produce systemic effects. Seek emergency
medical attention if an overdose is suspected.
More Information
Use caution when taking Cleocin T together
with neuromuscular blocking agents.
CLEOCIN T Topical Solution and CLEOCIN T Topical
Lotion contain clindamycin phosphate, USP, at a concentration equivalent to 10
mg clindamycin per milliliter. CLEOCIN T Topical Gel contains clindamycin
phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram.
Each CLEOCIN T Topical Solution pledget applicator contains approximately 1 mL
of topical solution.
Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic
produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent
antibiotic lincomycin.
The solution contains isopropyl alcohol 50% v/v, propylene glycol, and water.
The gel contains allantoin, carbomer 934P, methylparaben, polyethylene glycol
400, propylene glycol, sodium hydroxide, and purified water.
The lotion contains cetostearyl alcohol (2.5%); glycerin; glyceryl stearate SE
(with potassium monostearate); isostearyl alcohol (2.5%); methylparaben (0.3%);
sodium lauroyl sarcosinate; stearic acid; and purified water.
The chemical name for clindamycin phosphate is
Methyl
7-chloro-6,7,8-trideoxy-6-(1- methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-
1-thio-L-threo-á-D-galacto-octopyranoside 2-(dihydrogen phosphate).
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