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Buspar®
(buspirone HCl, USP)
Drug Uses
Buspar is used to treat generalized
anxiety disorder. Your doctor may use this medicine to treat other conditions as
well. Buspar affects the chemicals in your brain that may have become unbalanced
and are causing anxiety.
How Taken
Take Buspar with food or milk if stomach
upset occurs. It is important to take this medication exactly as prescribed. Do
not increase your dose or take more often than prescribed. Symptoms will begin
to improve within 7 to 10 days of starting this medication. However, it may take
3 to 4 weeks for the full benefit of the medication to be apparent.
Warnings/Precautions
Before taking Buspar, tell your doctor
your medical history especially: kidney or liver disease, any drug allergies.
Limit alcohol intake as it may intensify the dizziness and/or drowsiness effects
of Buspar. Use caution when engaging in activities requiring alertness such as
driving. Tell your doctor if you are pregnant before using this drug. It is not
known if this drug is excreted into breast milk. Consult your doctor before
breast-feeding.
Missed Dose
Take your next dose as soon as you
remember. If it is time for your next dose, skip the missed dose and go back to
your regular schedule. Do not double doses.
Possible Side Effects
Buspar may cause drowsiness, dizziness,
lightheadedness, fatigue, weakness, vivid dreams, sleeplessness, dry skin,
blurred vision, altered sense of taste and smell, weight gain, muscle aches,
ringing in the ears, nausea, and headaches. If these effects persist or worsen,
notify your doctor. Notify your doctor if you experience: abnormal movements or
"twitches" of the face or neck muscles, other involuntary movements or tremors,
depression, confusion, incoordination, chest pain, breathing difficulties. If
you notice other effects not listed above, contact your doctor or pharmacist.
Storage
Keep this medication in the container it
came in, tightly closed, and out of reach of children. Store it at room
temperature and away from excess heat and moisture (not in the bathroom). Throw
away any medication that is outdated or no longer needed.
Overdose
If overdose is suspected, contact your
local poison control center or emergency room immediately. Symptoms of overdose
may include nausea, vomiting, dizziness, drowsiness, and decreased pupil size.
More Information
Before taking Buspar tell your doctor of
all over-the-counter or prescription drugs you may use especially: other drugs
for anxiety or depression, azole or macrolide antibiotics, haloperidol, narcotic
pain medications. Do not eat grapefruit or drink grapefruit juice unless your
doctor instructs you otherwise. Do not start or stop any medicine without doctor
or pharmacist approval.
Buspar® (buspirone hydrochloride tablets, USP) is
an anti anxiety agent that is not chemically or pharmacologically related to the
benzodiazepines, barbiturates, or other sedative/anxiolytic drugs.
Buspirone hydrochloride is a white crystalline, water soluble compound with a
molecular weight of 422.0. Chemically, buspirone hydrochloride is
8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-aza-spiro[4.5]decane-7,9-dione monohydrochloride.
The empirical formula is C21H31N502•HCl
Buspar is supplied as tablets for oral administration containing 5 mg, 10 mg, 15
mg, or 30 mg of buspirone hydrochloride, USP (equivalent to 4.6 mg, 9.1 mg, 13.7
mg, and 27.4 mg of buspirone free base, respectively). The 5-mg and 10-mg
tablets are scored so they can be bisected. Thus, the 5-mg tablet can also
provide a 2.5-mg dose, and the 10-mg tablet can provide a 5-mg dose. The 15-mg
and 30-mg tablets are provided in the DIVIDOSE® tablet design. These tablets are
scored so they can be either bisected or trisected. Thus, a single 15-mg tablet
can provide the following doses: 15 mg (entire tablet), 10 mg (two thirds of a
tablet), 7.5 mg (one half of a tablet), or 5 mg (one third of a tablet). A
single 30-mg tablet can provide the following doses: 30 mg (entire tablet), 20
mg (two thirds of a tablet), 15 mg (one half of a tablet), or 10 mg (one third
of a tablet). Buspar Tablets contain the following inactive ingredients:
colloidal silicon dioxide, lactose, magnesium stearate, microcrystalline
cellulose, and sodium starch glycolate. The 30-mg tablet also contains iron
oxide.
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