|
| |
Augmentin
XR™
(amoxicillin/clavulanate potassium)
Extended Release Tablets
Also see: Amoxicillin
Prevacid
Amikacin
Amikin Amoxil Augmentin
Augmentin ES Biaxin
Prevpac
Trimox
Generic
Name: amoxicillin and clavulanate
potassium
Brand Names: Augmentin, Augmentin
ES-600, Augmentin XR
Amoxicillin is an active component in many
prescription medications. Amoxicillin is an antibiotic.
Amoxicillin and clavulanate potassium is
an antibiotic in a group of drugs called
penicillins. Amoxicillin and clavulanate
potassium fights bacteria in the body.
Amoxicillin and clavulanate potassium is
used to treat many different infections
caused by bacteria, such as sinusitis,
pneumonia, ear infections, bronchitis,
urinary tract infections, and infections
of the skin.
Amoxicillin and clavulanate potassium
may also be used for purposes.
To reduce the development of drug-resistant bacteria and maintain the
effectiveness of AUGMENTIN XR (amoxicillin/clavulanate potassium) and other
antibacterial drugs, AUGMENTIN XR should be used only to treat or prevent
infections that are proven or strongly suspected to be caused by bacteria.
AUGMENTIN XR is an oral antibacterial combination consisting of the
semisynthetic antibiotic amoxicillin (present as amoxicillin trihydrate and
amoxicillin sodium) and the ß-lactamase inhibitor clavulanate potassium (the
potassium salt of clavulanic acid). Amoxicillin is an analog of ampicillin,
derived from the basic penicillin nucleus 6-aminopenicillanic acid. The
amoxicillin trihydrate molecular formula is C16H19N 3O5S·3H2O, and the molecular
weight is 419.45. Chemically, amoxicillin trihydrate is (2S,5R,6R)-
6-[(R)-(-)-2-Amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]
heptane-2-carboxylic acid trihydrate.
The amoxicillin sodium molecular formula is C16H 18N3NaO 5S, and the molecular
weight is 387.39. Chemically, amoxicillin sodium is
[2S-[2α,5α,6β(S*)]]-6-[[Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]
heptane-2-carboxylic acid monosodium salt.
Clavulanic acid is produced by the fermentation of Streptomyces clavuligerus. It
is a β-lactam structurally related to the penicillins and possesses the ability
to inactivate a wide variety of β -lactamases by blocking the active sites of
these enzymes. Clavulanic acid is particularly active against the clinically
important plasmid-mediated β-lactamases frequently responsible for transferred
drug resistance to penicillins and cephalosporins. The clavulanate potassium
molecular formula is C8H8KNO5, and the molecular weight is 237.25. Chemically,
clavulanate potassium is potassium (Z)-(2R,5R)- 3-(2-hydroxyethylidene)-7-oxo-4-
oxa-1-azabicyclo[3.2.0]- heptane-2-carboxylate.
Inactive Ingredients
Citric acid, colloidal silicon dioxide, hypromellose, magnesium stearate,
microcrystalline cellulose, polyethylene glycol, sodium starch glycolate,
titanium dioxide, and xanthan gum.
Each tablet of AUGMENTIN XR contains 12.6 mg (0.32 mEq) of potassium and 29.3 mg
(1.27 mEq) of sodium.
|
