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Aciphex®
(rabeprazole sodium delayed-release
tablets)
Drug Uses
Aciphex decreases the amount of acid
produced in your stomach. Aciphex is used to treat ulcers, gastroesophageal
reflux disease (GERD or heartburn), and other conditions involving excessive
stomach acid production.
How Taken
Aciphex is available for oral
administration as delayed-release, enteric-coated tablets. The recommended adult
oral dose is one Aciphex 20 mg delayed-release tablet to be taken once daily for
four to eight weeks. Take each dose with a full glass of water. Do not break,
chew, or split the tablets. Swallow them whole. They are specially formulated to
release slowly in your body.
Warnings/Precautions
Before taking Aciphex, tell your doctor if
you are taking any of the following medicines: ketoconazole (Nizoral),
ampicillin (Omnipen, Principen), iron (Feosol, Mol-Iron, Fergon, Femiron,
others), digoxin (Lanoxin, Lanoxicaps), or cyclosporine (Sandimmune, Neoral).
You may not be able to take Aciphex, or you may require a dosage adjustment or
special monitoring during your treatment if you are taking any of the medicines
listed above. Drugs other than those listed here may also interact with Aciphex.
Talk to your doctor and pharmacist before taking any prescription or
over-the-counter medicines.
Missed Dose
If you miss a dose, use it as soon as you
remember. If it is near the time of the next dose, skip the missed dose and
resume your usual dosing schedule. Do not "double-up" the dose to catch up.
Possible Side Effects
Serious side effects from Aciphex are
rare. Stop taking Aciphex and seek emergency medical attention if you experience
an allergic reaction (difficulty breathing; closing of your throat; swelling of
your lips, tongue, or face; or hives) to Aciphex. Less serious side effects from
Aciphex are also uncommon. Continue to take Aciphex and talk to your doctor if
you experience headache; upset stomach or diarrhea; insomnia or nervousness; or
a rash or itching. Side effects other than those listed here may also occur.
Talk to your doctor about any side effect that seems unusual or that is
especially bothersome.
Storage
Keep Aciphex out of the reach of children.
Store Aciphex at room temperature (between 59°F and 86°F). Protect Aciphex from
moisture.
Overdose
Symptoms of an Aciphex overdose are not
known. Seek emergency medical attention.
More Information
There are no restrictions on food,
beverages, or activity while taking Aciphex, unless otherwise directed by your
doctor. Do not stop taking Aciphex even if you begin to feel better. Your
symptoms may improve before your condition is fully treated.
Rabeprazole decreases the
amount of acid produced in your stomach.
Rabeprazole is used to treat ulcers, gastroesophageal reflux disease (GERD or
heartburn), and other conditions involving excessive stomach acid production.
Rabeprazole may also be used for purposes
The active ingredient in
ACIPHEX® Delayed-Release Tablets is rabeprazole sodium, a substituted
benzimidazole that inhibits gastric acid secretion. Rabeprazole sodium is known
chemically as
2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]-methyl]sulfinyl]-1H–benzimidazole
sodium salt.
It has an empirical formula of C18H20N3NaO3S and a molecular weight
of 381.43. Rabeprazole sodium is a white to slightly yellowish-white solid. It
is very soluble in water and methanol, freely soluble in ethanol, chloroform and
ethyl acetate and insoluble in ether and n-hexane. The stability of rabeprazole
sodium is a function of pH; it is rapidly degraded in acid media, and is more
stable under alkaline conditions.
ACIPHEX® is available for oral administration as delayed-release, enteric-coated
tablets containing 20 mg of rabeprazole sodium. Inactive ingredients are
carnauba wax, crospovidone, diacetylated monoglycerides, ethylcellulose,
hydroxypropyl cellulose, hypromellose phthalate, magnesium stearate, mannitol,
sodium hydroxide, sodium stearyl fumarate, talc, titanium dioxide, and yellow
ferric oxide as a coloring agent.
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